三昇体育

通讯地址：三昇博彩石先楼102

电 话：23503703

电子邮件：[email protected]

课题组网站：

研究领域：新农药创制，招生学科：农药学、资源利用与植物保护

1998/09-2002/06，中国农业大学，应用三昇体育，学士

2002/09-2007/06，三昇博彩，三昇体育元素有机化学研究所，博士

2007/12-今，三昇博彩，三昇体育农药国家工程研究中心，元素有机化学研究所工作

1. 2024年，中国国际大学生创新大赛天津赛区产业命题赛道，获优秀指导教师

2. 2025年，中国国际大学生创新大赛天津赛区产业命题赛道，获优秀指导教师

1. Di Zhang , Liang Li, Chunxue Wang, Nuo Zhou, Zhilei Yu, Tianyi Shen, Baifan Wang, Qiang Bian, Dejun Ma, Yucheng Gu, Han Xu*, Zhen Xi*. A Novel Dual- Target Compound Designed With Potent Herbicidal and Fungicidal Activity Inspired by Conserved Phytoene Synthase Domains. Plant Biotechnol. J. 2026, 24, 2903-2913.

2. Di Zhang, Kunpeng Yang, Yuting Fan, Ding Jia, Dejun Ma, Yu-Cheng Gu, Han Xu*, Zhen Xi*Design, Synthesis, and Bioactivity of 2,4-Diphenylquinoline Derivatives as Novel 1-Deoxy-d-xylulose-5-phosphate Synthase Inhibitors. J. Agric. Food Chem. 2026,74,20309-20318.

3. Di Zhang, Ding Jia, Kunpeng Yang, Yuting Fan, Dejun Ma, Yucheng Gu, Han Xu*, Zhen Xi*. Discovery of (4-Phenyl-4H-1,2,4-triazol-3-yl)methyl Phenylcarbamate as Potent Dual-Inhibitors Targeting Phytoene Desaturase and ζ-Carotene Desaturase. J. Agric. Food Chem. 2025, 73, 29448−29458.

4. Di Zhang, Chunxue Wang, Tianyi Shen, Dejun M, Yucheng Gu, Han Xu*, Zhen Xi*. Functional Identification of 1‑Deoxy‑D‑Xylulose -5-Phosphate Synthase (DXPS) as an Effective Herbicide Target for the Discovery of Novel Potent Inhibitors through Virtual Screening. J. Agric. Food Chem. 2025, 73, 14839−14849.

5. Di Zhang, Chunxue Wang, Yichi Zhang, Zhilei Yu, Zeyu Hong, Ding Jia, Dejun Ma, Yucheng Gu, Han Xu*, Zhen Xi*, Discovery of Novel (5-Mercapto-4-phenyl-4H-1,2,4-triazol-3-yl) methyl Phenyl Carbamate as a Potent Phytoene Desaturase Inhibitor through Scaffold Hopping and Linker Modification. J. Agric. Food Chem. 2024, 72, 18898-18908.

6. Di Zhang, Nuo Zhou, Lijun Yang, Zhilei Yu, Dejun Ma, Dawei Wang, Yonghong Li, Bin Liu, Baifan Wang, Han Xu*, Zhen Xi*, Discovery of (5-(Benzylthio)-4-(3-(trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-yl) Methanols as Potent Phytoene Desaturase Inhibitors through Virtual Screening and Structure Optimization. J. Agric. Food Chem. 2022, 70, 10144-10157. 

7. Lijun Yang, Dawei Wang, Di Zhang, Nuo Zhou, Jing Wang, Han Xu*, Zhen Xi*, In silico structure-guided optimization and molecular simulation studies of 3-phenoxy-4-(3-trifluoromethylphenyl)pyridazines as potent phytoene desaturase inhibitors. Molecules 2021, 26, 6979. 

8. Han Xu, Youquan Zhu, Xiaomao Zou, Bin Liu, Yong Wang, Fangzhong Hu, Huazheng Yang*, Synthesis and herbicidal activities of novel 3-(substituted benzyloxy or phenoxy)-6-methyl-4-(3-trifluoromethylphenyl) pyridazine derivatives, Pest. Manag. Sci. 2012, 68, 276-284 

9. Han Xu, Xuhong Hu, Xiaomao Zou, Bin Liu, Youquan Zhu,You-Quan; Yong Wang, Fangzhong Hu, Huazheng Yang*,Synthesis and herbicidal activities of novel 3-N-substituted amino-6-methyl-4- (3-trifluoromethylphenyl)pyridazine derivatives, J. Agric. Food Chem. 2008, 56, 6567-6572 

10. Han Xu,, Xiaomao Zou, Youquan Zhu, Liu B, Bin Liu, Xuhong Hu, Haibin Song, Fangzhong Hu, Yong Wang,  Huazheng Yang*, Synthesis and herbicidal activity of novel α, α, α-trifluoro-m-tolyl pyridazinone derivatives. Pest. Manag. Sci., 2006, 62, 522-530.

11. 杨华铮; 邹小毛; 朱有全; 杨光富; 胡方中; 任雪玲; 许寒; 李华斌 ; 现代农药化学, 化学工业出版社, 2013 

12. 席真，许寒，张迪，周诺，杨丽君，王大伟，李永红，刘斌，三唑类化合物及其制备方法和应用以及除草剂，中国发明专利，申请日：2021.11.25，申请号：202111415539.X，公开日：2022.03.29，公开号：114249698A，授权日期：2024.02.13，专利号：ZL 202111415539.X，专利权人：三昇博彩

13. 席真，许寒，杨丽君，王大伟，张迪，马德君，李永红，刘斌，一种哒嗪类化合物及其应用，中国发明专利，申请日：2021.10.21，申请号：202111227514.7，公开日：2022.03.04，公开号：114133356 A，授权日期：2023.06.16，专利号：ZL 202111227514.7，专利权人：三昇博彩

14. 席真，许寒，张迪，周诺，余智磊，李永红，刘斌，三唑类化合物及其制备方法和应用以及杀菌剂，中国发明专利，申请日：2022.12.16，申请号：202211628061.3，申请公开日：2024.06.18，申请公开号：CN 118206503 A，授权日期：2026年8月18日，专利权人：三昇博彩

15. 许寒，席真，张迪，张一弛，洪泽宇，余智磊，一种含三唑环结构的化合物及其制备方法和应用、一种除草剂，中国发明专利，申请日：2024.08.05，申请号：202411066304.8，申请人：三昇博彩

16. 许寒，席真，张迪，张一弛，洪泽宇，余智磊，一种含三唑环结构的化合物及其制备方法和应用、一种除草剂，中国发明专利，申请日：2024.08.05，申请号：202411066194.5，申请人：三昇博彩

17. 许寒，席真，张迪，杨锟鹏，王永硕，洪泽宇，一种含三氮唑结构的化合物及其制备方法和应用、一种农药除草剂，中国发明专利，申请日：2025.10.24，申请号：202511532858.7，申请人：三昇博彩

已毕业硕士研究生14人